SAMe-TT₂R₂ Score

Predict warfarin TTR suitability vs DOAC preference in AFib

Variables

Sex female+1 ptAge < 60 years+1 ptMedical history: ≥2 of — hypertension, diabetes, CAD/MI, PAD, CHF, prior stroke, pulmonary disease, hepatic/renal disease+1 ptTreatment with interacting drugs (amiodarone, antifungals, etc.)+1 ptTobacco use within 2 years+2 ptsRace non-Caucasian+2 pts

0Good Warfarin Candidate

Likely to achieve good TTR on warfarin. Warfarin may be appropriate if preferred.

DOAC preferred in most new AFib patients. SAMe-TT₂R₂ is useful when warfarin is being considered (e.g., mechanical valve, CrCl <15, patient preference).

For clinical decision support only. Does not replace provider judgment. Verify all scores before acting on results.