SAMe-TT₂R₂ Score

Predict warfarin TTR suitability vs DOAC preference in AFib

Variables

Sex female+1 ptAge < 60 years+1 ptMedical history: ≥2 of — hypertension, diabetes, CAD/MI, PAD, CHF, prior stroke, pulmonary disease, hepatic/renal disease+1 ptTreatment with interacting drugs (amiodarone, antifungals, etc.)+1 ptTobacco use within 2 years+2 ptsRace non-Caucasian+2 pts

0Good Warfarin Candidate

Likely to achieve good TTR on warfarin. Warfarin may be appropriate if preferred.

DOAC preferred in most new AFib patients. SAMe-TT₂R₂ is useful when warfarin is being considered (e.g., mechanical valve, CrCl <15, patient preference).

In clinical review. This calculator follows the published score, but our clinical review hasn’t signed off on this implementation yet. Verify every result against the primary source before acting on it.

For clinical decision support only. Does not replace provider judgment. Verify all scores before acting on results.